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Date of Acceptance: December 13, 2019 Abbreviations: reactive oxygen species, ROS

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Lilly also reported higher rates of dysesthesia and urinary tract infections among participants receiving retatrutide than placebo in both studies

A 2024 review in Circulation summarized the skeletal-muscle data across multiple GLP-1 trials and concluded that the observed changes appear adaptive rather than pathological. In March 2026, Langer and colleagues published a direct test of the muscle question in Cell Reports Medicine, albeit in mice